Benefits of Moderate Weight Loss
↑ Lung function in asthma (≥10kg)1
↓ Arthritis related disability (≥5%)2
↓ Blood pressure (≥ 10kg)3,4,5,6,7,8
↓ 3.8-4.4mmHg in DBP (5kg) or 4.6mmHg (10kg)
↓ 3.0-3.6mmHg in SBP (5kg) or 6mmHg (10kg)
↓ 58% in development of DM in IGT at 3 years (5kg)9,10
↓ Total cholesterol ~0.21mmol at 12m (5kg), ~0.25mmol at 2-5yr (10kg)3,11
↓ LDL cholesterol ~0.13mmol at 12m (5kg), ~0.22mmol (10kg)3
↓ triglycerides ~0.19mmol at 12m (5kg)3
↑ HDL cholesterol ~0.06mmol at 12m (5kg)3
Total mortality3
↓ diabetes-related deaths (≥5kg)
↓ obesity-related cancer deaths (5-10kg)
References
1. Stenius-Aarniala B, Poussa T, Kvarnstorm J, Gronlund EL, Ylirahri M, Mustajoki P. Immediate and long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technology Assessment 2004:8 (21).
2. Christensen R, Bartels EM, Astrup A, Bliddal H. Effects of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis. Annals of Rheumatic Diseases 2007; 66(4):433-9.
3. Avenell A, Broom J, Brown TJ, Poobalan A, Aucott L, Stearns SC, et al. Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement. Health Technology Assessment 2004; 8(21).
4. Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM. Influence of weight reduction on blood pressure: a meta-analysis of randomised controlled trials. Hypertension 2003; 42 (5): 878-84
5. Mulrow CD, Chiquette E, Angel L, Cornell J, Summerbell C, Anagnostelis B, et al. Dieting to reduce body weight for controlling hypertension in adults. The Cochrane Library. 2006 (4)(CD000484).
6. Vettor R, Serra R, Fabris R, Pagano C, Federspil G. Effects of sibutramine on weight management and metabolic control in type 2 diabetes: a meta analysis of clinical studies. Diabetes Care 2005; 28(4): 942-9.
7. Aucott L, Poobalan A, Smith WC, Avenell A, Jung R, Broom J. Effects of weight loss in overweight/ obese individuals and long-term hypertension outcomes: a systematic review. Hypertension 2005; 45 (6): 1035-41.
8. Douketis JD, Macie C, Thabane L, Williamson DF. Systematic review of long- term weight loss studies in obese adults: Clinical significance and applicability to clinical practice. International Journal of Obesity. 2005; 29 (10): 1153-67
9. McTigue KM, Harris R, Hemphill B, Lux L, Sutton S, Bunton AJ, et al. Screening and interventions for obesity in adults: summary of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 2003; 139 (11): 933-49, I-57.
10. Ferchak CV, Meneghini LF. Obesity, bariatric surgery and type 2 diabetes- a systematic review. Diabetes/ Metabolism Research Reviews 2004; 20(6):438-45.
11. Poobalan A, Aucott L, Smith WC, Avenell A, Jung R, Broom J, et al. Effects of weight loss in overweight/obese individuals and long term lipid outcomes- a systematic review. Obesity Reviews 2004; 5(1):43-50.